Jean,
I was able to contact JulHussey, the direct descendant of Esther Skelly. She confirmed that she did indeed have her DNA tested by Ancestry. Unfortunately, she is not showing a DNA connection to anyone in my family. It looks like I can rule out that particular Skelly family from Castletown. So I believe that leaves JS who is 20 in the 1841 census?
Thanks,
KRM