I agree that Thomas is s/o John Caine & Isabel Key
Thomas & Isabella Cannell md 30 Apr 1811 Braddan
I don't know when Thomas or Isabella died
I have 10 children for them including Margaret ch 11 Oct 1829
However, I have her md #1 Robert Quiggin 4 Dec 1852 and #2 Charles Quayle 16 Aug 1870

CHR: 11 Oct 1829 Braddan Parish Christening Records FHL Film #0106
708 daughter of Thomas Caine and Isabella Cannell.

!FIRST MARRIAGE: 4 Dec 1852 Kirk Braddan Parish Marriage Record FHL
Film #0106188 married Robert Quiggin son of Thomas Quiggin and Ann Cannell. They had 7 children.

!SECOND MARRIAGE: 16 Aug 1870 Kirk Braddan Parish Marriage Record
FHL Film #0106189 married Charles Quayle of Douglas. They had 3
children one of which died infant(Charles Albert Quayle)

!DEATH: 29 Oct 1904 Margaret Caine Quiggin Quayle died age 73 per
Baldwin(Braddan) St Lukes Monumental Inscription Book #178:
In loving memory of Margaret of Charles Quayle of Douglas and relict of
Robert Quiggin of Eary Ween, Baldwin who died Oct. 29th 1904 aged 73
yrs. "At Rest" Also the above named Charles Quayle who died Dec. 27th
1917 aged 65 yrs.

Regards,
Donna