I don't have much on this family.
John Quine married Isobel Creech, 27 Oct 1741 at Onchan.
John I have not researched. Isobel has been discussed in this thread.

Their children, all bp Braddan, were:-
Alice, 2 Jan 1742
John, 4 Apr 1745
John, 27 Mar 1748
Thomas, 3 Apr 1753
Margaret, 27 Feb 1757
Isabel, 3 Feb 1760
Patrick, 30 Jan 1763

The 21 years between Alice and Patrick indicates there may be two different families.

My interest was with John, 1748, who apears to have married Margaret Clague.