I posted this sometime ago to a query re Jewish presence on Island - there were a few Jews on the Island pre revestment (eg Philip Levi acted as interpreter), a couple caused 'problems' for the church when they 'converted' in order to marry

Not sure if any stayed after 1765 but in 1830's there was Joseph Saqui brother of a famous cantor and choirmaster in Liverpool who was involved in early Oddfellows, returned to Island as a tobacconist -
+ on my oddfellows page
22 Jul 1838 :The lodge at Laxey made a presentation to Mr Saqui of the Oddfellows' Arms, Laxey in recognition of his exertions as NG [Noble Grand]of that lodge.
(Joseph Saqui (1809-) was an older brother of the famous Abraham Saqui, first choirmaster Liverpool's Princes Road Orthodox Synagogue and well-known for his still extensively sung "Songs of Israel" - Abraham was reported as being born in London but moving to Liverpool early in life, another brother Jacob (John) ran a Jewellers shop in Liverpool - Joseph removed briefly to Douglas where he opened the Oddfellows' Arms on North Quay in 1840, is found with wife Esther in 1841 but is then found running a boarding house, 18 Lord Nelson Street Liverpool (an address shared by Abraham Saqui, Professor of Music), until reappearing as a tobacconist at Prospect Hill/Gt Nelson St, Douglas by 1861 - in 1881 census shown with a younger wife Margaret and family).

you can find several refs to his trade etc on manxnotebook - tabline above